Serum Procalcitonin for Differentiating Bacterial Infection from Disease Flares in Patients with Autoimmune Diseases

نویسندگان

  • Kowoon Joo
  • Won Park
  • Mie-Jin Lim
  • Seong-Ryul Kwon
  • Jiyeol Yoon
چکیده

Early differentiation between bacterial infections and disease flares in autoimmune disease patients is important due to different treatments. Seventy-nine autoimmune disease patients with symptoms suggestive of infections or disease flares were collected by retrospective chart review. The patients were later classified into two groups, disease flare and infection. C-reactive protein (CRP) and serum procalcitonin (PCT) levels were measured. The CRP and PCT levels were higher in the infection group than the disease flare group (CRP,11.96 mg/dL ± 9.60 vs 6.42 mg/dL ± 7.01, P = 0.003; PCT, 2.44 ng/mL ± 6.55 vs 0.09 ng/mL ± 0.09, P < 0.001). The area under the ROC curve (AUC; 95% confidence interval) for CRP and PCT was 0.70 (0.58-0.82) and 0.84 (0.75-0.93), which showed a significant difference (P < 0.05). The predicted AUC for the CRP and PCT levels combined was 0.83, which was not significantly different compared to the PCT level alone (P = 0.80). The best cut-off value for CRP was 7.18 mg/dL, with a sensitivity of 71.9% and a specificity of 68.1%. The best cut-off value for PCT was 0.09 ng/mL, with a sensitivity of 81.3% and a specificity of 78.7%. The PCT level had better sensitivity and specificity compared to the CRP level in distinguishing between bacterial infections and disease flares in autoimmune disease patients. The CRP level has no additive value when combined with the PCT level when differentiating bacterial infections from disease flares.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

اندازه گیری سطح سرمی پروکلسی‌تونین در بیماران مشکوک به آنفولانزای خوکی (H1N1)

Abstract Background: Measurement of serum level of procalcitonin in patients with H1N1 influenza could decrease the consumption of unnecessary antibiotics. This study aimed to determine the serum levels of procalcitonin in patients with swine flu (H1N1) in the Hajar Hospital of Shahrekord in 2011. Materials and Methods: In this cross-sectional study patients presenting with clinical manifestati...

متن کامل

Serum Procalcitonin Is a Candidate Biomarker to Differentiate Bacteremia from Disease Flares in Patients with Inflammatory Bowel Disease

In patients with inflammatory bowel disease (IBD), discriminating between bacterial infections and disease flares is often difficult due to the similar clinical presentations and laboratory findings. The differentiation in patients with IBD is important because treatments for each clinical condition are different and commonly opposite. Especially, early detection and treatment of infection in t...

متن کامل

Diagnostic value of procalcitonin measurement in febrile patients with systemic autoimmune diseases.

OBJECTIVE To determine the usefulness of plasma procalcitonin (PCT) measurement to suspect infectious etiology in febrile patients with systemic autoimmune disease. METHODS PCT, C-Reactive protein (CRP), erythrocyte sedimentation rate (ESR) and white blood cell count (WBC) were measured in 44 consecutive inpatients with a diagnosis of systemic autoimmune disease and fever >38 masculine C. Aft...

متن کامل

ارزش تشخیصی سطح سرمی پروکلسیتونین در افتراق مننژیت باکتریال از غیرباکتریال در کودکان یک ماهه تا 18 ساله مرکز طبی کودکان ، 83-1382

Background: Bacterial meningitis is a fatal disease with high mortality and morbidity that needs emergency management. But due to nonspecific signs and symptoms it;aposs diagnosis in children is difficult. Recently procalcitonin has been used for diagnosis of serious bacterial infections like bacterial meningitis. We conducted a prospective study in children for evaluation of procalcitonin in d...

متن کامل

پروکلسی‌تونین سرمی یک عامل پیش‌بینی‌‌کننده پاسخ به درمان در بیماران مبتلا به سپسیس باکتریال بستری در ICU

Background: Sepsis is one of the most important causes of mortality in severely ill ICU patients. At least, a part of high mortality rate in sepsis patients is due to less specific clinical symptoms for prompt diagnosis. Recently some studies report that serum levels of procalcitonin will increase in these patients but changes of serum levels following treatments is not known. This study was de...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 26  شماره 

صفحات  -

تاریخ انتشار 2011